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We will basically consider, in this focus, the problems posed in clinical practice by ambiguous sexual developments and how to solve them, the pathogenic considerations being mentioned only insofar as they are necessary for the comprehension, and thus to the treatment of abnormalities of sexual development. Let us insist from the outset on the absolute necessity of an early diagnosis, since any mistake in the sex attributed to a child is with catastrophic consequences on the somatic and psychological levels, because from around the age 3, the child becomes so fixed in his "psychological sex" that any "change of sex" becomes an extremely hazardous enterprise, if not impossible.